2 edition of Effects of halogenated aromatic compounds on the metabolism of foreign organic compounds found in the catalog.
Effects of halogenated aromatic compounds on the metabolism of foreign organic compounds
Gary P Carlson
by U.S. Environmental Protection Agency, Research and Development, Center for Environmental Research Information [distributor] in Research Triangle Park, NC, Cincinnati, OH
Written in English
|Statement||Gary P. Carlson|
|Contributions||Health Effects Research Laboratory (Research Triangle Park, N.C.)|
|The Physical Object|
|Pagination||8 p. :|
Aromatic compounds are produced from petroleum and coal tar. Key Terms. aromatic hydrocarbon: A compound having a closed ring of alternate single and double bonds with delocalized electrons. aromaticity: The property of organic compounds that have at least one conjugated ring of alternate single and double bonds, and exhibit extreme stability. Hydrocarbons are the simplest organic compounds, but they have interesting physiological effects. These effects depend on the size of the hydrocarbon molecules and where on or in the body they are applied. Alkanes of low molar mass—those with from 1 to approximately 10 or so carbon atoms—are gases or light liquids that act as anesthetics.
Electrophilic Aromatic SubstitutionThe electron-rich benzene makes a bond with an electron-deficient chemical species (E +, the electrophile) which takes the place of an H-atom in the original structure. The reaction preserves the pi system of electrons and therefore the aromatic character of the benzene ring. Sources of Aromatic Compounds. Chemical industry - Chemical industry - Halogens and their compounds: The first large-scale use of chlorine was in the manufacture of bleaching powder for use in making paper and cotton textiles. Bleaching powder was later replaced by liquid chlorine, which also came into widespread use as a germicide for public water supplies. Presently the principal use of chlorine is in making chemical.
Many organic compounds have cyclic structures. Organic Chemistry - Alkanes & Halogenated Hydrocarbons Hydrocarbons are the simplest organic compounds, but they have interesting physiological effects. These effects depend on the size of the hydrocarbon molecules and where on or in the body they are applied. Overview of Persistent Halogenated Aromatic Poisoning By. Robert W. Coppock Exposure begins during embryologic development and continues with possible differing toxic effects occurring during development, maturation, and aging. (P) and other enzymes. Changes in drug metabolism can occur. Changes in CYP activity can increase the.
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United States Environmental Protection Agency Health Effects Research Laboratory Cincinnati OH vvEPA Research and Development EPA/S Apr Project Summary Effects of Halogenated Aromatic Compounds on the Metabolism of Foreign Organic Compounds Gary P. Carlson This work was initiated to extend our previous findings on the induction of xenobiotic metabolism.
Majid Saidi, Aliakbar Ghaffari, in Design and Operation of Solid Oxide Fuel Cells, Volatile organic compounds. Other gas trace compounds (i.e., alkanes, alcohols, aromatics, halogenated hydrocarbons) typically found in waste-derived fuels are also known to cause detrimental effects on fuel-cell catalysts [23,].Chlorine is the most abundant form of halogens, whereas bromine.
IX.C Organic Compounds. Aluminum does not react with most hydrocarbons, saturated or unsaturated, aliphatic or aromatic. Most pure halogenated hydrocarbons and other halogenated organic compounds do not react with aluminum, except at elevated temperatures or in the presence of water, which causes hydrolysis.
However, some halogenated organic. Halogenation of aromatic compounds. Aromatic compounds are subject to electrophilic halogenation: RC 6 H 5 + X 2 → HX + RC 6 H 4 X. This reaction works only for chlorine and bromine and is carried in the presence of a Lewis acid such as FeX 3 (laboratory method).
The role of the Lewis acid is to polarize the halogen-halogen bond, making the halogen molecule more electrophilic. The book contains papers on human exposure and health effects; hepatotoxicity and carcinogenicity; and cytotoxicity, teratogenicity, mutagenicity, and neurotoxicity.
The text also presents papers on the metabolism and toxicodynamics of halogenated hydrocarbons, as well as the embryotoxicity and environmental fate related to halogenated Book Edition: 1.
Volatile halogenated and aromatic hydrocarbons as well as organophosphorus pesticides have a variety of harmful health effects. The U.S. Environmental Protection Agency (EPA) esti-mates that volatile organic compounds are present in one-fifth of the nation's water supplies.
They can enter ground water from a variety of sources. Benzene, for. Abstract. The metabolism of halogenated hydrocarbons in vivo is initiated predominantly by two classes of enzymes—the cytochrome Pdependent monooxygenases and the glutathione enzymes, in general, convert nonexcretable lipophilic compounds ultimately to hydrophilic metabolites that can be eliminated in urine and/or bile.
There are numerous hazards associated with exposure to halogenated aromatic hydrocarbons. The effects can vary considerably, depending on the type of compound. As a group, toxicity of the halogenated aromatic hydorcarbons has been associated with acute irritation of the eyes, mucous membranes and lungs, as well as gastrointestinal and.
Wackett LP () Bacterial co-metabolism of halogenated organic compounds. In: Young LY, Cerniglia C (Eds) Microbial Transformation and Degradation of Toxic Organic Chemicals (pp –).
Wiley-Liss, New York Google Scholar. Henk-Jan Drenth, Carolien A. Bouwman, Willem Seinen, Martin Van den Berg, Effects of Some Persistent Halogenated Environmental Contaminants on Aromatase (CYP19) Activity in the Human Choriocarcinoma Cell Line JEG-3, Toxicology and Applied Pharmacology, /taap,1, (), ().
Appendix III to Part - List of Halogenated Organic Compounds Regulated Under § In determining the concentration of HOCs in a hazardous waste for purposes of the § land disposal prohibition, EPA has defined the HOCs that must be included in a calculation as any compounds having a carbon-halogen bond which are listed in this.
The flammability of these materials is variable. The low-molecular-weight materials (gases and liquids) are generally dangerously flammable. However, many halogenated organic compounds of high molecular weight, in particular those containing several halogen atoms per molecule, are nonflammable; some are in fact used as fire retardants.
Greig JB, De Matteis F. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on drug metabolism and hepatic microsomes of rats and mice. Environ Health Perspect. Sep; – [PMC free article] [Google Scholar] Poland A, Greenlee WF, Kende AS.
Studies on the mechanism of action of the chlorinated dibenzo-p-dioxins and related compounds. COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.
HALOGENATED VOLATILE ORGANIC COMPOUNDS. Sites where halogenated VOCs may be found include burn pits, chemical manufacturing plants or disposal areas, contaminated marine sediments, disposal wells and leach fields, electroplating/metal finishing shops, firefighting training areas, hangars/aircraft maintenance areas, landfills and burial.
Halogenated compounds are included in the list of persistent compounds of the Canadian Guidance Manual () like: aromatic-I, aromatic-F, aromatic-Cl, aliphatic-Cl, aliphatic-Br, trifluoromethyl. To name halogenated hydrocarbons given formulas and write formulas for these compounds given names.
Many organic compounds are closely related to the alkanes. As we noted previously, alkanes react with halogens to produce halogenated hydrocarbons, the simplest of which have a single halogen atom substituted for a hydrogen atom of the alkane. Halogenated Solvents List Reference Manual Appendix A Halogenated Solvent List Arsenic Compounds, Inorganic K 1 4 Ceramic Fibers R 7 83 Chromium Hexavalent Compounds K 1 22 (See Polycyclic Aromatic Hydrocarbons) R 5 PBBs R Polybrominated Biphenyls (PBBs) R.
Ch16 Aromatic Compounds (landscape).docx Page 7 Failures of the Resonance Picture for Aromatics If having these identical resonance structures were the sole cause of this pronounced stability, then ALL structures with conjugated systems of alternating double and single bonds should show analogous enhanced stabilities.
These cyclic hydrocarbons with alternating double and single carbon carbon. In this review we discuss the degradation of chlorinated hydrocarbons by microorganisms, emphasizing the physiological, biochemical, and genetic basis of the biodegradation of aliphatic, aromatic, and polycyclic compounds.
Many environmentally important xenobiotics are halogenated. Possible Mechanism of Liver Necrosis Caused by Aromatic Organic Compounds Article (PDF Available) in Proceedings of the National Academy of Sciences 68(1) .The halogenated aromatic compounds have been important intermediates for various synthetic methods.
Electron-rich aromatic compounds were easily iodinated using tetrabutylammonium peroxydisulfate (1) and iodine in mild conditions with excellent ation was achieved using 1 and bromine, and regioselective bromination of highly activated aromatic compounds was also .Many functional groups can be added to aromatic compounds via electrophilic aromatic substitution reactions.
A functional group is a substituent that brings with it certain chemical reactions that the aromatic compound itself doesn't display. The bromination of benzene. All electrophilic aromatic substitution reactions share a common mechanism.